PCLinuxOS: I'd wait until the 2009 version comes out
Mandriva: It does GNOME well, and KDE4 isn't all that bad either. It has a nice computer control center.
Fedora: When I was able to install it (bad burns on my part) it was very nice
openSUSE: It's alright. YaST is getting better.
Debian: Nice and stable because it's conservative.
Of course at the end of the day it's up to you to decide what you want to do. Try them all out if you really want to using Virtualbox. It scratches my itch.
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