What has me really curious here is that I have used external drives interchangeable with Windows XP and Kubuntu. I have had...
1. 40GB (fat32)
2. 160 GB (fat32)
3. 250GB (ntfs)
4. 500GB (ntfs)
5. 500GB (100GB NTFS, 400GB ext3)
I have mounted the first 4 with USB and the last with eSATA. The only time I ever experienced a problem, I tried to hotswap a drive from USB to Firewire; that was a sad lesson in "not smart".
Have you tried a driver update? I searched around for a bit, and there appears to be some issues with the Maxtor OneTouch 3 and 4 with Vista. Do you have a Win XP machine you can connect the drive to? That might help confirm this.
I might not have the answer off-the-cuff, but I'm not going to give up yet!
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