Something is weird with the communication between pulseaudio and the alsa-drivers. I use ubuntu-studio for audio production with jack, and found that the jack-sink for pulseaudio works well. There's no sync problem when jack sits between pulseaudio and alsa. Whatever I do to make pulseaudio use the same samplerate (48k) and formats (s24le) as jack makes no difference. Standalone pulseaudio with direct connection to alsa is useless with any of my audio-adapters (Intel HDA, Roland 2ch USB, Behringer X32 mixer w/32ch USB, Soundcraft digital mixer w/32ch FW, Presonus 8ch USB).
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