Pretty much everything, even though I work with multimedia programs everyday;
I run a few games with Wine (All those I use the most. Perfect), and programs like Photoshop, Illustrator, Dreamweaver, Flash Pro, Audition in a Windows XP virtual machine.
The only programs I can't use at all under Ubuntu, even with a VM, are Adobe Premiere, AfterEffect and 3DS Max 2013 (I've installed it in a VM, but it lag a big, and even with OpenGL display, it's glitchy. Hardly usable).