I have a Dell Precision 390 with an 80GB hard drive that has Ubuntu 12.04 installed across the entire partition, and a 40GB drive for standard storage. Things were actually pretty good until I connected the 40GB drive that already had the fonts stored on it. I did transfer the fonts back and forth a few times from the 40GB to the 80GB and back again, I didn't really know the best place to put them, they were in a folder on the Unity Desktop for a while. There are thousands upon thousands of them.
I also installed Inkscape (graphic design program) and The Fonty Python Font Manager program. I began putting together font lists and installing them.
It was at this point that I noticed that the computer could no longer handle more than one program at a time. Even calling up the processes list would not work, it simply would not pop up. I would eventually shut the whole computer off manually and restart.
Other additional programs installed that did not originally come with Ubuntu include the Screensaver (also kept on my desktop for easy accessibility) and the Compiz Config. The desktop cube is not activated at the moment.
I initially started all of this in 11.04, and recently upgraded to 12.04.
I have never added more RAM than what initially came with this computer
At one point one of my 40GB drives began to fail, so I transfered everything to the 80GB drive, switched out the 40GB with another one, and then transfered everything back from the 80GB to the new 40GB drive.
Other issues include not being able to put pictures and images back onto the pendrive I got them off of in the first place. Transferring large pieces of data in one large folder is also a no-no, I cannot even delete info in large quantities, I have to do it one folder at a time.
I want speed, but am assuming I did something stupid when I added the fonts, maybe there are just too many, but I thought keeping them on a separate hard drive would help, on the other hand, maybe that's a bad Idea.