Based off that message you don't have the games repo for 12.1 enabled, you have the games repo for 11.3. 11.3 went end of life January 20th, 2012 and would be the reason why it cannot reach that repository. Remove that repo, enable the 12.1 games repo, then update your system.
Going forward please try and provide the output that is requested of you by people trying to help you. We could have solved this a number of posts ago if you had provided some decent information.
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