I made it work with PSPICE 9.1 and wine 1.0.1 with Ubuntu Jaunty by doing the following:

1) I installed it in a directory with no spaces in it.
2) I followed the advice of the person above. You need a PSPICEEV.INI that is known to work with the installed version on a Windows machine, and then edited with the appropriate path names.

I hope this helps someone else.