I got Skyrim to install and I haven't had any problems with it aside from the fact that I have VERY low FPS. Even with everything in the graphics options set to "low" and "off" it never goes above 20 FPS. Playing on ultra makes it totally unplayable, however the game runs smoothly on "ultra" on Windows 7. My specs:

Nvidia Geforce GTX 550 TI (1 GB)
AMD Athlon II X4 635 2.9 GHZ quad core CPU
Ubuntu 12.04 and windows 7, both x64
Wine 1.4

If anyone can give me some tips on stuff to tweak so it'll run like Windows 7, that would be greatly appreciated!