No Signal when booting pc when I have a USB plugged in with Ubuntu on it

[garb10]

What I've down so far is downloaded Ubuntu 16.04 LTS, and used RUFUS on the ISO & my USB to make it bootable. But when I restart my computer to boot the installer my computer just sits there with a no signal message.

I can provide more details but I'm not sure what would help and I didn't see a guideline. I apologize if I missed a resource or something that could easily answer this. I'm very end user but I'm willing to learn.

[yancek]

Did you do an md5 checksum to verify the Ubuntu iso download?
Can you try booting the usb in another computer to see if it boots?
How old/new is the computer and have you ever booted a usb from it before?
Have you changed the boot priority in the BIOS to set the usb drive to first boot priority?

[garb10]

I think it's a hardware issue now because I can't access the BIOS setup on startup either. Thanks for your time though.