Firstly make sure your running the latest version here
Secondly make sure you run winecfg before running win32 programs the first time.
Thirdly you can check your programs compatibility with wine here
Fourthly Good luck! and don't be afraid to ask more detailed questions, some people actually prefer more details like the name of the program your trying to run and such.
Sunday, May 04, 2008 9:00 PM PDT -- This would be a good time for Microsoft to change course and stop vowing to catch Google in search advertising. "That game is over and Google won," Li said. -- PC World