Hardware: Logitech MK320 Wireless Keyboard and Mouse combo
OS: Ubuntu Studio 10.10 (AMD64)
Functionality: Plug and play; works straight out of the box. Most of the hotkeys (volume up/down/mute, calculator, mail, sleep) work as well. A few of the hotkeys (Internet, lock screen) do not, but that's just a matter of configuration, I'm sure.
Overall, I was very impressed! A good product made excellent by the fact that it plays so nicely with Linux.