As long as we're bringing back old threads, I thought I'd give my opinion.
I like Qt because it's the only API I know well enough to get anything done in. I tried GTK+ for about ten minutes once and stopped when I realized it was written in C and gtk_functions_look_like_this(). I don't know whether the C++ wrapper or PyGTK improve on this, though.
I haven't tried wxWidgets in a long time, but why switch toolkits when I'm already happy?
Knowing Qt is a plus for other reasons- since KDE is built on it, it'll be much easier to migrate should I decide to write a desktop-integrated application.
Qt Designer is a nice program for my purposes.
Tk is ugly and Zenity is for shell scripts. Sorry.
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