Same here.
I've installed Ubuntu 14.04.01 in a VirtualBox machine. The virtual disk is stored in an external USB 3.0 HD. This installation is fine and stable. Themes and fonts configuration work perfectly in Unity Tweak Tool and Appearance menu of Ubuntu.
However, after installing Ubuntu in my "physical" machine (not a virtual machine), which has an SSD, a lot of bugs happen.
I can't change themes and font renderization configurations. Choosing a different theme (other than Ambiance), either in Unity Tweak Tool or Appearance (Ubuntu System Settings) menu, does nothing. Choosing different font hinting options in Unity Tweak Tool also does nothing.
I didn't have this problem in the past, in Ubuntu 10.04 version, before this aberration called "Unity" has been introduced.
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