I assume the thread title is the error you are seeing. As far as I know, this generally means that the grub boot loader cannont find the drive it is looking for to boot from.
The first thing I would do is open the box and make sure all cables to the hard drive(s) are seated properly. You say this is a custom build that you have bought, so it has presumably been transported recently. That makes checking the connections inside all the more relelvant.
I assume the machine was working for your friend. Did the transport go well? No nasty knocks or anything? No chance of damage during transport?
I would probably also boot into the live environment and see if I can see the drive with the file manager there or with the drive management tools there. The live environment is when you boot an Ubuntu install CD or USB into the "try Ubuntu without installing" option. It is a useful way to look at a computer that wont boot by itself.
If you want to try and get the ubuntu boot running again, go here
https://help.ubuntu.com/community/Boot-Repair
You could try the boot repair that it offers, or generate the boot info as described there and post the link to it here so that people can see the state of the machine. Someone should be able to help you get it going. I would tend to the boot info to see if the machine is finding all the drives it has.
If you really don't have any interest in getting the Ubuntu going, then I can only second schragge's advice: stick the windows installer in it an boot that. If that doesn't work, someone might be able to help your if your describe exactly what it going wrong, but installing windows is more a question for a Windows forum.
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