I upgraded last night to 12.10 and since have had a fair few issues, the worst though is with Libre Office.
Sometimes when it loads a spreadsheet the entire screen goes black and the machine is totally unresponsive and I have to hard reset it.
Other problems include the menu bar not working and most bizzarely the issues you can see in the spreadsheet where the text on columns, rows and worksheets is just a pixelated mess. This also happens when typing in data to cells, it will appear as a pixelated mess until I hit return. You can also see things like font and font size are unreadable.