Major problems I have:
1) USB drives no longer get detected automatically when plugged in (it worked fine in 12.04)
2) VMPlayer 5.0.0 wrecks the video mode on startup (it worked fine in 12.04)
3) gnome shell overview's right side virtual desktop overview stops working almost immediately on startup (this mostly - but not always - worked in 12.04)
64bits / ASUS EAH3650 (ATI) graphics card
I know 12.10 is not a LTS, but still...