Thanks for the input. I am trying that now but getting bad format error. I will try to get it working with some wine/playonlinux research and get the format correct.
Currently, the line in my bash script is as follows
With the exception of adding the keyword 'wine', this is basically a copy paste from the 'Command' line, in the 'Basic' tab of the desktop icon for diablo 3.
wine /user/defaultlocation/playonlinux/playonlinux --run "Diablo III"
Thank you for a push in the right direction, and I will post again if I fail or succeed in making it run.