This is quite old, but I'm having the same problem. I followed jprice's advice, and this is what is in the mysql_error.log file:
Code:
121120 18:24:06 mysqld_safe Starting mysqld daemon with databases from /opt/lampp/var/mysql
121120 18:24:06 [Note] Plugin 'FEDERATED' is disabled.
/opt/lampp/sbin/mysqld: Can't find file: './mysql/plugin.frm' (errno: 13)
121120 18:24:06 [ERROR] Can't open the mysql.plugin table. Please run mysql_upgrade to create it.
121120 18:24:06 InnoDB: Started; log sequence number 0 44233
121120 18:24:06 [ERROR] /opt/lampp/sbin/mysqld: Can't find file: './mysql/host.frm' (errno: 13)
121120 18:24:06 [ERROR] Fatal error: Can't open and lock privilege tables: Can't find file: './mysql/host.frm' (errno: 13)
121120 18:24:06 mysqld_safe mysqld from pid file /opt/lampp/var/mysql/Yasin.pid ended
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