I have a similar problem after installing 10.10 on my desktop. I have tried two different USB mice but to no avail. I installed the aforementioned .deb package but that did not help.
My problem is that sometimes the mouse buttons work and sometimes they do not. It seems that, more than not, clicking the window-bars or the gnome-panels has the effect of suspending my mouse buttons. Sometimes the keyboard to. (The keyboard is a PS2 keyboard).
I have not pressed any media-buttons or such.
:~$ xinput --list
⎡ Virtual core pointer id=2 [master pointer (3)]
⎜ ↳ Virtual core XTEST pointer id=4 [slave pointer (2)]
⎜ ↳ Gaming Mouse1600 Gaming Mouse1600 id=8 [slave pointer (2)]
⎣ Virtual core keyboard id=3 [master keyboard (2)]
↳ Virtual core XTEST keyboard id=5 [slave keyboard (3)]
↳ Power Button id=6 [slave keyboard (3)]
↳ Power Button id=7 [slave keyboard (3)]
↳ AT Translated Set 2 keyboard id=9 [slave keyboard (3)]