I do some pretty heavy 25-man raiding in World of Warcraft, currently using an Asus UL30VT-laptop (with NVidia G210) with Ubuntu exclusively installed.
My performance under Ubuntu with Wine on this laptop actually surpasses the performance I had under Windows XP/7 on my stationary 1.83GHz Intel core duo with NVidia Geforce 9600 (not an amazing system by far, but a few years ago it was decent at least).
With that said, I haven't really tried any other games under Wine lately. Blizzard have always been known for being good at not breaking their code so much that the Wine-team can't come up with fixes for Wine.
The only thing that bugs me out a bit is that there still isn't support for hardware mouse acceleration in OpenGL-mode, which makes especially healing in 25-man raids awkward due to all the mouse movement required, but a fix for this has been announced by Blizzard for the upcoming Cataclysm-expansion.
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