I had that problem that when I wanted to start PH (after I have finished firefly's tutorial) a little window poped up: Photoshop complaining about that I should reinstall Adobe Application Manager 'cos it's damaged...
So, I have downloaded this little program for it (from www.adobe.com). Tried to install of course it install to some degree but then it died. The solution for this was to copy the c:\Program Files\Common Files\Adobe for wine to /home/$USER/.wine/drive_c/Program Files/Common Files/
After this I have joined the happy bunnies on the farm
Hope this will help someone one day