Failed to work for me.
Running ubuntu 10.04.
Installed wine ok and selected Vista as my windows of choice - tried xp previously with little success.
Downloaded the exe from wizard101.com and opened with wine windows program loader. it did a little program installation thing as in windows(rather quickly).
Tried launching from the icon on the desktop and from the wine program menu and it sat there for about 20 seconds as if it was starting something and then stopped and ... nothing.

ON the wizard101 site firefox tells me that I need a plugin to see all the content of the page. When I try to install the suggested adobe flash, I get half way through and then... installation failed. So the next time i tried gnome type flash player which installs but I cannot see the live action on the website and there is the note that I need adobe flash player to see the page correctly. Multiple things not working here.