Running a 2 day old Karmic install when all my sound went.
Installing paman showed the 'Connection refused' message and the message /home/xxxxxx is not ours
Reading around, I found that pulseaudio is run on a user session basis and needs access to the /home directory. I check nautilus and it seems my userid permissions were changed.
Basically changed my home folder permissions back to my userid and group id and all worked after a reboot.