Does this means that it won't run in virtual pc?
Not necessarily. Gameguard and Hackshield should have no problems running in a virtual machine, however, since most virtual machine software apps do not support accelerated 3D graphics, the games still might not work.
Maple Story Is No Longer A Game Guard File. Its HackSheild
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To my knowlege the game Maple Story uses GameGuard protection, and will not work under wine.
They recently switched to hackshield.