Are you using 64-bit Wine? I've found a very old forum post that suggested 32-bit Wine as a workaround for this problem with this game. It's not one...
You don't even have to plug anything in for the assignments to change; it's just whichever drive happens to spin up first and claim the earlier name....
It's a long time since I did it, so I can't remember any details, but I recall that I had to sudo -i and echo something somewhere to get sound out of...
You don't need to uninstall KDE, just force the version to a lower one. You can do it all in Synaptic, although there are command-line equivalents.
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You could probably use xrandr to ping the monitors awake by setting the resolution of both of them to what they should be. You might even be able to...